Contract type : Public service fixed-term contract
Level of qualifications required : Graduate degree or equivalent
Fonction : PhD Position
About the research centre or Inria department
Grenoble Rhône-Alpes Research Center groups together a few less than 800 people in 35 research teams and 9 research support departments.
Staff is localized on 5 campuses in Grenoble and Lyon, in close collaboration with labs, research and higher education institutions in Grenoble and Lyon, but also with the economic players in these areas.
Present in the fields of software, high-performance computing, Internet of things, image and data, but also simulation in oceanography and biology, it participates at the best level of international scientific achievements and collaborations in both Europe and the rest of the world.
The position is based in project-team IBIS at Inria Grenoble - Rhône-Alpes (https://team.inria.fr/ibis/). IBIS includes experimental biology personnel at the Laboratoire Interdisciplinaire de Physique (LIPhy, 140 Av. de la physique, Grenoble; https://www-liphy.ujf-grenoble.fr/Introduction-627) of the Université Grenoble-Alpes.
Our interdisciplinary group, composed of biologists, computer scientists, mathematicians and physicists, studies bacteria, in particular E.coli, at the level of the population and at the single-cell level. Our main focus is fundamental research, but we also aim at applications in biotechnology and synthetic biology.
The project includes data analysis and modelling tasks to be carried out at Inria, as well as experimental biology tasks carried out at LIPhy. Funding is available via the Inria Project-Lab CoSy (https://project.inria.fr/iplcosy/).
Different species in natural bacterial communities generally communicate in complicated ways. Our aim is to
construct precisely defined bacterial communities consisting of engineered strains of E.coli. Using this synthetic system, we will be able to analyze and control the interactions between different subpopulations. In particular, we will engineer bacteria that communicate by metabolites that are released in the medium and control the temporal expression profile of particular genes in the two populations by optogenetics. The main focus is fundamental research, with possible applications in biotechnology.
The PhD project consists in constructing some of the strains, analyzing their behavior by measuring gene expression and growth parameters, and controlling their temporal dynamics using an advanced platform of mini-bioreactors coupled to a cytometer. By this setup, our aim is to achieve feedback control not only of mean behavior, but also of variability of growth and gene expression between and within subpopulations.
- Strain construction
- Platform programming and execution of experiments
- Data analysis
- Implementation of (existing) bacterial community control algorithms
Possible additional activities:
- Model calibration, paper reading, report writing
Applicants may come from different disciplinary backgrounds – physics, biology, engineering, and computer science. Basic knowledge in microbiology is required and previous experience with some of the techniques mentioned in the project description would be appreciated.
Good relational skills are important for the project, as it will be carried out in an interdisciplinary and international environment.
Familiarity with English is appreciated.
- Subsidized meals
- Partial reimbursement of public transport costs
- Leave: 7 weeks of annual leave + 10 extra days off due to RTT (statutory reduction in working hours) + possibility of exceptional leave (sick children, moving home, etc.)
- Possibility of teleworking (after 6 months of employment) and flexible organization of working hours
- Professional equipment available (videoconferencing, loan of computer equipment, etc.)
- Social, cultural and sports events and activities
- Access to vocational training
- Social security coverage
Gross salary :
- 1982€ during the 1st and 2nd year
- 2085€ the third year
- Theme/Domain :
Biologie et santé, Sciences de la vie et de la terre (BAP A)
- Town/city : Montbonnot
- Inria Center : CRI Grenoble - Rhône-Alpes
- Starting date : 2019-09-01
- Duration of contract : 3 years
- Deadline to apply : 2019-06-30
The keys to success
We expect candidates to be strongly motivated by collaborative and interdisciplinary research combining experimental work in the lab with modeling of biological systems and data analysis.
Inria, the French national research institute for the digital sciences, promotes scientific excellence and technology transfer to maximise its impact. It employs 2,400 people. Its 200 agile project teams, generally with academic partners, involve more than 3,000 scientists in meeting the challenges of computer science and mathematics, often at the interface of other disciplines. Inria works with many companies and has assisted in the creation of over 160 startups. It strives to meet the challenges of the digital transformation of science, society and the economy.
Instruction to apply
Defence Security :
This position is likely to be situated in a restricted area (ZRR), as defined in Decree No. 2011-1425 relating to the protection of national scientific and technical potential (PPST).Authorisation to enter an area is granted by the director of the unit, following a favourable Ministerial decision, as defined in the decree of 3 July 2012 relating to the PPST. An unfavourable Ministerial decision in respect of a position situated in a ZRR would result in the cancellation of the appointment.
Recruitment Policy :
As part of its diversity policy, all Inria positions are accessible to people with disabilities.
Warning : you must enter your e-mail address in order to save your application to Inria. Applications must be submitted online on the Inria website. Processing of applications sent from other channels is not guaranteed.