2019-01733 - Post-Doctoral Research Visit F/M Modélisation des tissus en base d'agents.

Contract type : Public service fixed-term contract

Renewable contract : Oui

Level of qualifications required : PhD or equivalent

Fonction : Post-Doctoral Research Visit

About the research centre or Inria department

Inria, the French National Institute for computer science and applied mathematics, promotes “scientific excellence for technology transfer and society”. Graduates from the world’s top universities, Inria's 2,700 employees rise to the challenges of digital sciences. With its open, agile model, Inria is able to explore original approaches with its partners in industry and academia and provide an efficient response to the multidisciplinary and application challenges of the digital transformation. Inria is the source of many innovations that add value and create jobs.

Context

INRIA has developed a strong expertise in mathematical modeling of biological systems with medical applications.
Working closely with clinicians from several renowned French and German hospitals and one of the best biology and toxicology institutes in Germany, the team Mamba at its INRIA collaborators have been working on the liver for many years, developing models of liver lesions and regeneration, including tissue lesions of the micro-architecture of the liver. They are currently involved in various projects, including the study of fibrosis to help the development of clinical treatments, the development of a liver created by bioengineering and the study of hepatic intoxication due to paracetamol.
Recently, the activities are also extended to other disesases auch as lymphoma of the central nervous system, where similar methodologies can be applied.

Assignment

The position will be under the main direction of D. Drasdo. It includes a collaboration with Hôpital Paul Brousse & Le Kremlin-Bicêtre/INSERM, Hôpital Universitaire La Pitié Salpêtrière, Paris, Inst. Curie, and the INRIA team Monc / Bordeaux within two projects, one funded by ANR, the second by the Natl. Inst. of Cancer in France. This requires regular meetings with medical doctors.

The candidate should refine current agent-based models and modeling methods to mimic tissue organisation processes mainly at the histological level. This consists in adapting the agent-based models to new applications within the following fields: disease processes and regeneration in liver micro-architecture, in vitro systems and lymphomas of the central nervous system (PCNSL). The models will be set up, parameterized and validated based on image information. Hence, interest or/and skills in image analysis are welcome.

The recruited person should meet with clinicians and coordinate our activities with internal and external partners.

Main activities

Main activities :

  • Development of agent-based models
  • Coding the models
  • Testing the code
  • Running agent-based model simulations on different applications in biotechnology and medicine
  • Communication with biologists and clinicians.

 

 

Skills

Technical skills and level required :

  • Knowledge, ideally experience, on modeling with agent-based models
  • Sound knowledge in mechanics
  • Good coding skills in C/C++
  • Basic knowledge of numerics
  • Sound knowledge in modeling biological systems
  • Linux, windows

Languages : English (compulsory), French if possible (but not mandatory)

Benefits package

    • Subsidized meals
    • Partial reimbursement of public transport costs
    • Leave: 7 weeks of annual leave + 10 extra days off due to RTT (statutory reduction in working hours) + possibility of exceptional leave (sick children, moving home, etc.)
    • Possibility of teleworking (after 6 months of employment) and flexible organization of working hours
    • Professional equipment available (videoconferencing, loan of computer equipment, etc.)
    • Social, cultural and sports events and activities
    • Access to vocational training

Remuneration

Salary based on experience, full benefits