Bayesian adaptive phase I-II trials for drug resistant infection
Contract type : Fixed-term contract
Renewable contract : Yes
Level of qualifications required : PhD or equivalent
Fonction : Temporary scientific engineer
Context
Within the framework of the PEPR SN SMATCH.
This research project focuses on integrating mechanistic mathematical models, that link the dose regimen to the concentration and/or the efficacy markers, into the design model and the dose escalation process of a Phase I/II clinical trial. Clustering techniques will be added to the code aiming at early identification of responding patients. A Bayesian framework will be used and decisions will be made on predicted probability of successes for each enrolled patient.
Assignment
Collaborations:
The recruited person will be in connection with the whole SMATCH consortium (https://pepr-santenum.fr/2023/11/07/smatch/ ).
Responsibilities :
Mission 1: Looking for innovative methods to improve existing models.
Mission 2: Translating models into codes and software.
Main activities
Main activities :
- Bibliography search of existing approaches;
- Improving the coding and explanations of dose-finding methods;
- Testing and adjiusting the code;
- Participating in scientific articles writing;
- Participating to conferences.
Skills
Technical skills and level required:
- Advance knowled in mathematics (pure or applied)
- R and/or Phyton coding
Languages:
- Fluent in English
Relational skills:
- Feel confortable to work in a team
Benefits package
- Subsidized meals
- Partial reimbursement of public transport costs
- Leave: 7 weeks of annual leave + 10 extra days off due to RTT (statutory reduction in working hours) + possibility of exceptional leave (sick children, moving home, etc.)
- Possibility of teleworking and flexible organization of working hours
- Professional equipment available (videoconferencing, loan of computer equipment, etc.)
- Social, cultural and sports events and activities
- Access to vocational training
- Social security coverage
General Information
- Theme/Domain :
Computational Neuroscience and Medicine
Statistics (Big data) (BAP E) - Town/city : Paris
- Inria Center : Centre Inria de Paris
- Starting date : 2025-05-01
- Duration of contract : 1 year, 6 months
- Deadline to apply : 2025-02-22
Warning : you must enter your e-mail address in order to save your application to Inria. Applications must be submitted online on the Inria website. Processing of applications sent from other channels is not guaranteed.
Instruction to apply
Defence Security :
This position is likely to be situated in a restricted area (ZRR), as defined in Decree No. 2011-1425 relating to the protection of national scientific and technical potential (PPST).Authorisation to enter an area is granted by the director of the unit, following a favourable Ministerial decision, as defined in the decree of 3 July 2012 relating to the PPST. An unfavourable Ministerial decision in respect of a position situated in a ZRR would result in the cancellation of the appointment.
Recruitment Policy :
As part of its diversity policy, all Inria positions are accessible to people with disabilities.
Contacts
- Inria Team : HEKA
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Recruiter :
Ursino Moreno / moreno.ursino@inria.fr
About Inria
Inria is the French national research institute dedicated to digital science and technology. It employs 2,600 people. Its 200 agile project teams, generally run jointly with academic partners, include more than 3,500 scientists and engineers working to meet the challenges of digital technology, often at the interface with other disciplines. The Institute also employs numerous talents in over forty different professions. 900 research support staff contribute to the preparation and development of scientific and entrepreneurial projects that have a worldwide impact.