Post-Doctoral Research Visit F/M Multiscale Modeling of Dravet Syndrome
Type de contrat : CDD
Niveau de diplôme exigé : Thèse ou équivalent
Fonction : Post-Doctorant
A propos du centre ou de la direction fonctionnelle
Inria is a national research institute dedicated to digital sciences that promotes scientific excellence and transfer. Inria employs 2,400 collaborators organised in research project teams, usually in collaboration with its academic partners.
This agility allows its scientists, from the best universities in the world, to meet the challenges of computer science and mathematics, either through multidisciplinarity or with industrial partners.
A precursor to the creation of Deep Tech companies, Inria has also supported the creation of more than 150 start-ups from its research teams. Inria effectively faces the challenges of the digital transformation of science, society and the economy.
Contexte et atouts du poste
This job offer is part of a recently launched Inria’s exploratory action. This action, entitled Multiscale Modeling of Dravet Syndrome (2MDS), aims to develop a multi-scale modeling framework for channelopathies, a group of diseases caused by the dysfunction of membrane ion channels or their interacting proteins. These pathologies include Dravet syndrome (DS), a severe form of infantile epilepsy. We will study this class of pathologies at different scales, each with dedicated modeling and experimental tools, in close collaboration with a partner laboratory of the Basque Center for Applied Mathematics and with the Basque Center for Neuroscience.
Mission confiée
Assignments :
The aim of this project is to develop a detailed model of interacting neurons, where the voltage activity of each neuron is itself in interaction with the activity of families of ion channels, sodium and potassium, present along its axon. This model will be presented in the form of an interacting particle system, each particle evolving according to a piecewise-deterministic Markov process (PDMP). We will first focus on the dynamics of a single neuron, then on the dynamics of a neuron network of limited size where the randomness might not be averaged out. The considered mutation will be modeled at the level of the PDMP dynamics of ion channels.
We will also develop a simpler compartmental population model (healthy neurons/mutated neurons) in the form of a continuous-time Markov chain (CTMC). Under assumptions of channel independence and large channel population sizes, the CTMC model converges to the classical Hodgkin-Huxley model. It is therefore relevant to explore two tracks: on the one hand, how do these models behave in the presence of a channel population size that does not allow to wipe-out the randomness ? On the other hand, how do these models behave in the presence of correlation between the state of the channels ? This will allow us to simplify, at a meso-scale, the detailed stochastic model by proposing by diffusion approximation more practical stochastic differential equation models.
For large size neuron populations, the interaction term in the voltage equation for excita- tory neurons can also be simplified using a mean-field approximation. In the case of smaller populations, stochastic deviations from this mean-field approximation should also be considered.
For a better knowledge of the proposed research subject :
A state of the art, bibliography and scientific references are available at the following URL:
http://www-sop.inria.fr/members/Fabien.Campillo/projects/2mds
Collaboration :
The recruited person will be in connection with Fabien Campillo (MathNeuro, Montpellier), and Pierre Del Moral (Astral, Bordeaux), for stochastic modelling and Monte Carlo Simulation, and Mathieu Desroches (Mathneuro) and Serafim Rodrigues (MCEN, BCAM, Bilbao), for mathematical and applied neurosciences.
Principales activités
- within the Montpellier/Bordeaux/Bilbao network, the candidate will develop previous models and analyze them
- particular attention will be paid to the biological foundations of these models
- the candidate will also develop Monte Carlo tools for simulating these models and integrate them into a computational environment associated with the Bilbao experimental laboratory
- it may also be possible to confront these models with experimental data
- the candidate will be based in Montpellier and will travel regularly to Bordeaux and Bilbao, where he or she will meet with experimentalists in the field
Compétences
- Modeling, simulation and analysis of dynamical systems
- Markov processes, SDEs, PDMPs, Monte Carlo simulation
- skills in neuroscience
- programming skills, such as Python
Avantages
- Subsidized meals
- Partial reimbursement of public transport costs
- Leave: 7 weeks of annual leave + 10 extra days off due to RTT (statutory reduction in working hours) + possibility of exceptional leave (sick children, moving home, etc.)
- Possibility of teleworking and flexible organization of working hours
- Professional equipment available (videoconferencing, loan of computer equipment, etc.)
- Social, cultural and sports events and activities
- Access to vocational training
- Contribution to mutual insurance (subject to conditions)
Rémunération
Gross Salary: 2746 € per month
Informations générales
- Thème/Domaine :
Neurosciences et médecine numériques
Biologie et santé, Sciences de la vie et de la terre (BAP A) - Ville : Montpellier
- Centre Inria : Centre Inria d'Université Côte d'Azur
- Date de prise de fonction souhaitée : 2023-11-01
- Durée de contrat : 2 ans
- Date limite pour postuler : 2023-12-31
Attention: Les candidatures doivent être déposées en ligne sur le site Inria. Le traitement des candidatures adressées par d'autres canaux n'est pas garanti.
Consignes pour postuler
Sécurité défense :
Ce poste est susceptible d’être affecté dans une zone à régime restrictif (ZRR), telle que définie dans le décret n°2011-1425 relatif à la protection du potentiel scientifique et technique de la nation (PPST). L’autorisation d’accès à une zone est délivrée par le chef d’établissement, après avis ministériel favorable, tel que défini dans l’arrêté du 03 juillet 2012, relatif à la PPST. Un avis ministériel défavorable pour un poste affecté dans une ZRR aurait pour conséquence l’annulation du recrutement.
Politique de recrutement :
Dans le cadre de sa politique diversité, tous les postes Inria sont accessibles aux personnes en situation de handicap.
Contacts
- Équipe Inria : MATHNEURO
-
Recruteur :
Campillo Fabien / Fabien.Campillo@inria.fr
L'essentiel pour réussir
- a pronounced interest in numerical modeling in the life sciences
- strong aptitude for interdisciplinary collaborations
- collaborative communication skills
A propos d'Inria
Inria est l’institut national de recherche dédié aux sciences et technologies du numérique. Il emploie 2600 personnes. Ses 215 équipes-projets agiles, en général communes avec des partenaires académiques, impliquent plus de 3900 scientifiques pour relever les défis du numérique, souvent à l’interface d’autres disciplines. L’institut fait appel à de nombreux talents dans plus d’une quarantaine de métiers différents. 900 personnels d’appui à la recherche et à l’innovation contribuent à faire émerger et grandir des projets scientifiques ou entrepreneuriaux qui impactent le monde. Inria travaille avec de nombreuses entreprises et a accompagné la création de plus de 200 start-up. L'institut s'efforce ainsi de répondre aux enjeux de la transformation numérique de la science, de la société et de l'économie.